NootMind

Creativity

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for divergent thinking, idea generation, and associative cognition — ranked by effect score.

Energy

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for mental and physical energy, drive, and sustained stamina — ranked by effect score.

Focus

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for attention, concentration, and flow states — ranked by effect score.

Memory

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for recall, learning speed, and long-term retention — ranked by effect score.

Mood

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for stress resilience, anxiety reduction, and emotional wellbeing — ranked by effect score.

Sleep

Mon, 08 Jun 2026 01:00:04 GMT

Top compounds for sleep onset, quality, duration, and overnight recovery — ranked by effect score.

All Supplements by Mechanism

Sun, 07 Jun 2026 21:51:48 GMT

All Supplements by Mechanism Use this note to browse the wiki by mechanism rather than alphabetically.

Diet

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Diet This note is educational and is not personal medical advice.

Electrolytes

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Electrolytes This note is educational and is not personal medical advice.

Exercise

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Exercise This note is educational and is not personal medical advice.

Sleep

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Sleep This note is educational and is not personal medical advice.

Sugar

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Sugar This note is educational and is not personal medical advice.

Water

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Water This note is educational and is not personal medical advice.

Desired Effects Map

Sun, 07 Jun 2026 21:51:48 GMT

Desired Effects Map Focus, Learning, MemoryMood, Confidence, CreativitySleep, Calm, Emotional ControlEnergy & FatigueRecovery & RepairImproved EnergyBest fit: Sleep, Exercise, Creatine, Caffeine, Guarana, Rhodiola Rosea, Panax Ginseng.Mitochondrial / nutrient support: Acetyl-L-Carnitine, NAD...

Mechanism Pathway

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Mechanism Pathway

Mechanism Pathway Map

How the 13 core brain mechanisms influence each other.

Popular Stacks

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Popular Stacks Mr.

Synergy Web

Sun, 07 Jun 2026 21:51:48 GMT

Synergy Web Classic Stimulant PairsCaffeine + L-TheanineThe reference stack.

Adderall

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Adderall This note is educational and does not provide instructions for nonmedical use.

Amphetamines

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Amphetamines This note is educational and does not provide instructions for nonmedical use.

Kratom

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Kratom This note is educational and does not provide instructions for nonmedical use.

LSD

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LSD This note is educational and does not provide instructions for nonmedical use.

Marijuana

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Marijuana This note is educational and does not provide instructions for nonmedical use.

Modafinil

Sun, 07 Jun 2026 21:51:48 GMT

Modafinil This note is educational and does not provide instructions for nonmedical use.

Nicotine

Sun, 07 Jun 2026 21:51:48 GMT

Nicotine This note is educational and does not provide instructions for nonmedical use.

Phenibut

Sun, 07 Jun 2026 21:51:48 GMT

Phenibut This note is educational and is not personal medical advice.

Psilocybin

Sun, 07 Jun 2026 21:51:48 GMT

Psilocybin This note is educational and does not provide instructions for nonmedical use.

Ritalin

Sun, 07 Jun 2026 21:51:48 GMT

Ritalin This note is educational and does not provide instructions for nonmedical use.

Testosterone & Anabolics

Sun, 07 Jun 2026 21:51:48 GMT

Testosterone & Anabolics This note is educational and does not provide instructions for nonmedical use.

Cycling & Tolerance Guide

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Cycling & Tolerance Guide Tolerance is one of the most underappreciated variables in nootropic use.

Duration Guide

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Duration Guide Duration determines how to evaluate a nootropic.

Acute & Instant Effects

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Acute & Instant Effects What this duration category means Acute effects are felt within minutes to hours and are useful for same-day state changes: alertness, calm, blood flow, sleep onset, or symptom relief.

Long Term & Permanent Effects

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Long Term & Permanent Effects What this duration category means Long-term and potentially lasting effects involve structural learning, behavior change, neurorecovery, hormone remodeling, psychedelic psychological effects, training adaptations, and neurotrophic processes.

Medium Term & Saturation Effects

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Medium Term & Saturation Effects What this duration category means Medium-term effects build over days to weeks as tissue stores, receptor adaptations, inflammatory tone, nutrient status, or membrane composition change.

Evidence Rating Legend

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Evidence Rating Legend Every compound in this wiki carries an evidence_quality field in its frontmatter.

Knowledge Graph

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Knowledge Graph Every note in this wiki as a 3D force graph.

Live Rankings

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Community-voted compound rankings based on the past 6 months of upvotes and downvotes.

Adaptogens & Stress Modulators

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Adaptogens & Stress Modulators What this mechanism is Adaptogens and stress modulators influence the HPA axis, autonomic tone, fatigue perception, immune tone, and stress-induced neurotransmitter changes.

Anti-Inflammatory and Antioxidant Protection

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Anti-Inflammatory and Antioxidant Protection What this mechanism is This mechanism covers reduction of oxidative stress, inflammatory signaling, impaired recovery, and immune-brain stress loops.

Blood Flow & Circulation Enhancement

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Blood Flow & Circulation Enhancement What this mechanism is This mechanism covers compounds and behaviors that improve oxygen delivery, endothelial function, nitric oxide signaling, blood volume, or microcirculation.

Cholinergic System

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Cholinergic System What this mechanism is The cholinergic system uses acetylcholine for attention, learning, memory encoding, sensory gating, REM sleep, and neuromuscular signaling.

Dopamine Modulation

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Dopamine Modulation What this mechanism is Dopamine modulation affects motivation, reward learning, task initiation, movement, libido, and salience.

Glutamate, AMPA, NMDA Modulation

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Glutamate, AMPA, NMDA Modulation What this mechanism is Glutamate is the primary excitatory neurotransmitter and is essential for learning, memory, and plasticity.

Hormonal Modulation

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Hormonal Modulation What this mechanism is Hormonal mechanisms include cortisol, thyroid, insulin, testosterone/estrogen, melatonin, vitamin D, and oxytocin signaling.

Methylation & One-Carbon Metabolism

Sun, 07 Jun 2026 21:51:48 GMT

Methylation & One-Carbon Metabolism What this mechanism is Methylation and one-carbon metabolism move single-carbon units through folate, B12, choline/betaine, methionine, and SAMe pathways.

Mitochondrial & Energy Metabolism

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Mitochondrial & Energy Metabolism What this mechanism is This mechanism covers ATP production, phosphocreatine buffering, fatty-acid transport, NAD+/redox state, glucose handling, mitochondrial biogenesis, and metabolic cofactors.

Neurotransmitter Balance

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Neurotransmitter Balance What this mechanism is This mechanism covers modulation of dopamine, norepinephrine, serotonin, acetylcholine, GABA, glutamate, endocannabinoids, and neuropeptides.

Neurotrophic & Growth Factors

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Neurotrophic & Growth Factors What this mechanism is This mechanism covers BDNF, NGF, synaptogenesis, neurogenesis, repair signaling, and plasticity.

Sleep Support

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Sleep Support What this mechanism is Sleep-support mechanisms improve sleep timing, sleep onset, sleep continuity, circadian alignment, or nighttime nervous-system downshifting.

Wakefulness & Arousal

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Wakefulness & Arousal What this mechanism is Wakefulness mechanisms increase alertness through adenosine blockade, catecholamines, histamine, orexin, nicotine receptors, stimulant-like arousal, or metabolic fatigue resistance.

Nootropics Overview

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Nootropics Overview This is the central map for the wiki.

9-Me-Bc

Sun, 07 Jun 2026 21:51:48 GMT

9-Me-Bc This note is educational and is not personal medical advice.

ACD-856

Sun, 07 Jun 2026 21:51:48 GMT

ACD-856 This note is educational and is not personal medical advice.

Aniracetam

Sun, 07 Jun 2026 21:51:48 GMT

Aniracetam This note is educational and is not personal medical advice.

BPC-157

Sun, 07 Jun 2026 21:51:48 GMT

BPC-157 This note is educational and is not personal medical advice.

BPN-14770

Sun, 07 Jun 2026 21:51:48 GMT

BPN-14770 This note is educational and is not personal medical advice.

Bromantane

Sun, 07 Jun 2026 21:51:48 GMT

Bromantane This note is educational and is not personal medical advice.

Cerebrolysin

Sun, 07 Jun 2026 21:51:48 GMT

Cerebrolysin This note is educational and is not personal medical advice.

Coluracetam

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Coluracetam This note is educational and is not personal medical advice.

Cortexin

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Cortexin This note is educational and is not personal medical advice.

Dihexa

Sun, 07 Jun 2026 21:51:48 GMT

Dihexa This note is educational and is not personal medical advice.

Epithalon

Sun, 07 Jun 2026 21:51:48 GMT

Epithalon This note is educational and is not personal medical advice.

Methylene Blue

Sun, 07 Jun 2026 21:51:48 GMT

Methylene Blue This note is educational and is not personal medical advice.

NSI-189

Sun, 07 Jun 2026 21:51:48 GMT

NSI-189 This note is educational and is not personal medical advice.

Neboglamine

Sun, 07 Jun 2026 21:51:48 GMT

Neboglamine This note is educational and is not personal medical advice.

Nefiracetam

Sun, 07 Jun 2026 21:51:48 GMT

Nefiracetam This note is educational and is not personal medical advice.

Noopept

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Noopept This note is educational and is not personal medical advice.

Oxiracetam

Sun, 07 Jun 2026 21:51:48 GMT

Oxiracetam This note is educational and is not personal medical advice.

Oxytocin

Sun, 07 Jun 2026 21:51:48 GMT

Oxytocin This note is educational and is not personal medical advice.

PE-22-28

Sun, 07 Jun 2026 21:51:48 GMT

PE-22-28 This note is educational and is not personal medical advice.

Phenylpiracetam

Sun, 07 Jun 2026 21:51:48 GMT

Phenylpiracetam This note is educational and is not personal medical advice.

Pinealon

Sun, 07 Jun 2026 21:51:48 GMT

Pinealon This note is educational and is not personal medical advice.

Piracetam

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Piracetam This note is educational and is not personal medical advice.

Pramiracetam

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Pramiracetam This note is educational and is not personal medical advice.

Racetams

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Racetams This note is educational and is not personal medical advice.

Selank

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Selank This note is educational and is not personal medical advice.

Semax

Sun, 07 Jun 2026 21:51:48 GMT

Semax This note is educational and is not personal medical advice.

Tropisetron

Sun, 07 Jun 2026 21:51:48 GMT

Tropisetron This note is educational and is not personal medical advice.

Popularity Rankings

Sun, 07 Jun 2026 21:51:48 GMT

Popularity Rankings Popularity scores (1–10) reflect estimated community usage frequency based on Reddit survey data, supplement store sales signals, YouTube discussion volume, and nootropic community forum presence.

Safety & Contraindications

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Safety & Contraindications This wiki is educational.

5-HTP

Sun, 07 Jun 2026 21:51:48 GMT

5-HTP This note is educational and is not personal medical advice.

Acetyl-L-Carnitine

Sun, 07 Jun 2026 21:51:48 GMT

Acetyl-L-Carnitine This note is educational and is not personal medical advice.

Agmatine Sulfate

Sun, 07 Jun 2026 21:51:48 GMT

Agmatine Sulfate This note is educational and is not personal medical advice.

Alpha-GPC

Sun, 07 Jun 2026 21:51:48 GMT

Alpha-GPC This note is educational and is not personal medical advice.

Armodafinil

Sun, 07 Jun 2026 21:51:48 GMT

Armodafinil This note is educational and is not personal medical advice.

Ashwagandha

Sun, 07 Jun 2026 21:51:48 GMT

Ashwagandha This note is educational and is not personal medical advice.

B-Vitamins

Sun, 07 Jun 2026 21:51:48 GMT

B-Vitamins This note is educational and is not personal medical advice.

Bacopa Monnieri

Sun, 07 Jun 2026 21:51:48 GMT

Bacopa Monnieri This note is educational and is not personal medical advice.

Berberine

Sun, 07 Jun 2026 21:51:48 GMT

Berberine This note is educational and is not personal medical advice.

Beta-Caryophyllene

Sun, 07 Jun 2026 21:51:48 GMT

Beta-Caryophyllene This note is educational and is not personal medical advice.

Biotin (B7)

Sun, 07 Jun 2026 21:51:48 GMT

Biotin (B7) This note is educational and is not personal medical advice.

CBD

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CBD This note is educational and is not personal medical advice.

Caffeine

Sun, 07 Jun 2026 21:51:48 GMT

Caffeine This note is educational and is not personal medical advice.

Cat's Claw

Sun, 07 Jun 2026 21:51:48 GMT

Cat’s Claw This note is educational and is not personal medical advice.

Chaga

Sun, 07 Jun 2026 21:51:48 GMT

Chaga This note is educational and is not personal medical advice.

Chai

Sun, 07 Jun 2026 21:51:48 GMT

Chai This note is educational and is not personal medical advice.

Choline

Sun, 07 Jun 2026 21:51:48 GMT

Choline This note is educational and is not personal medical advice.

Citicoline

Sun, 07 Jun 2026 21:51:48 GMT

Citicoline This note is educational and is not personal medical advice.

CoQ10

Sun, 07 Jun 2026 21:51:48 GMT

CoQ10 This note is educational and is not personal medical advice.

Cordyceps

Sun, 07 Jun 2026 21:51:48 GMT

Cordyceps This note is educational and is not personal medical advice.

Creatine

Sun, 07 Jun 2026 21:51:48 GMT

Creatine This note is educational and is not personal medical advice.